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A meta-analysis that included 23 studies with 842 participants of randomized controlled trials that evaluated any biotic intervention in stage 3 to 4 CKD and also ESKD patients revealed that the biotics improved total antioxidative capacity and malondialdehyde and reduced the levels of IL-6

Ghezzi D, Arzuffi P, Zordan M, Da Re C, Lamperti C, Benna C, et al

If swelling becomes pronounced or is accompanied by other symptoms like shortness of breath, immediate medical evaluation is necessary

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